dU (Deoxyuridine) phosphoramidite

Cat. # Quantity Price Lead time
320-1g 1 g $60 in stock
320-10g 10 g $250 in stock
320-50g 50 g please inquire 21 days
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dU amidite enables the addition of deoxyuridine nucleoside to the DNA chain to synthesize modified oligonucleotides. Deoxyuridine (dU) is a derivative of the nucleoside uridine and has H instead of hydroxy group at the 2’-position of the ribose. This amidite contains DMT at the 5’-end.

Oligos modification with dU affects the melting profiles of oligo duplexes via integrating 2’-deoxyuridine into nucleic acid sequences.

dU (Deoxyuridine) phosphoramidite can serve for oligonucleotide probes and as a research tool for duplex stability studies and those of DNA damage and repair mechanisms.

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General properties

Appearance: white to pale yellow powder
Molecular weight: 730.79
CAS number: 109389-30-2
Molecular formula: C39H47N4O8P
IUPAC name: 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine-3'-O-[O-(2-cyanoethyl)-N,N'-diisopropylphosphoramidite]
Solubility: good in acetonitrile, DCM
Quality control: NMR 1H, NMR 31P, HPLC-MS (95%)
Storage conditions: Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate.
MSDS: Download
Product specifications

Oligo synthesis details

Diluent: acetonitrile
Coupling conditions: standard coupling, identical to normal nucleobases
Cleavage conditions: ammonia, 2 h at room temperature
Deprotection conditions: identical to protected nucleobases
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