Go Beyond the 20! Clickable amino acids for nascent protein synthesis
Site-specifically tag, crosslink, or functionalize proteins with unique handles (azides, alkynes) that react only with your probe — no background interference. Non-canonical Amino Acids are synthetic analogs of methionine or phenylalanine that are able to penetrate the cell and randomly incorporate into synthesizing protein instead of endogenous amino acid during translation.
Non-canonical amino acids and bioorthogonal chemistry are beneficial for spatiotemporal tracking of proteome dynamics using BONCAT (Bioorthogonal Non-Canonical Amino Acid Tagging) and FUNCAT (Fluorescent Non-Canonical Amino Acid Tagging) techniques, providing a precise tool for labeling, isolating, and visualizing newly synthesized proteins in living systems.
Try our Non-canonical Amino Acids for fast and sensitive bioorthogonal chemistry:
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AHA (L-Azidohomoalanine)Non-canonical amino acid analog of methionine with an azide moiety for nascent protein synthesis detection via copper-catalyzed and copper-free click chemistry. |
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HPG (L-Homopropargylglycine)Non-canonical amino acid analog of methionine with a terminal alkyne moiety for nascent protein synthesis detection. |
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4AZP (4-Azido-L-phenylalanine)Unnatural L-phenylalanine derivative with an azide moiety for nascent protein synthesis detection via copper-catalyzed and copper-free click chemistry. |
Discover more products for cell metabolic labeling in our Catalog and select fluorescently labeled counterparts for bioorthogonal chemistry in our Fluorophore Chart.
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