3-(5-methyl-1H-pyrazol-3-yl)propionic acid-d6 (MPP)
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 4337-500ug | 0.50 mg |
$259
|
20 days |
Succinylacetone (abbreviated as SA) is a product of tyrosine catabolism, and an inhibitor of heme biosynthesis. Succinylacetone testing in dried neonatal blood spots, followed by quantitation of SA in blood or urine in high-risk neonates, has excellent sensitivity and specificity for the diagnosis of tyrosinemia type 1 [1].
Succinylacetone is a reactive diketone which reacts with the amino groups of peptides and proteins present in the blood. Therefore, extraction of the bound SA requires its conversion into a product suitable for its extraction and quantification. This is effected by means of hydrazine treatment which leads to a conversion of succinylacetone to this pyrazole derivative.
This pyrazole derivative is a deuterated derivative is used as an analytical standard in the measurement of succinylacetone (SA) in dried blood spot samples.
[1] Kehar M., Sen Sarma M., Seetharaman J., Jimenez Rivera C., Chakraborty P. Decoding hepatorenal tyrosinemia type 1: Unraveling the impact of early detection, NTBC, and the role of liver transplantation. Can Liver J. 2024. 7(1). P.54-63.
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General properties
| Appearance: | white solid |
| Molecular weight: | 160.21 |
| Molecular formula: | C7H4D6N2O2 |
| Solubility: | in water |
| Quality control: | NMR 1H and HPLC-MS (95+ %, D: 98+ %) |
| Storage conditions: | 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate. |
| MSDS: | Download |
| Product specifications |
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