H-Met-AMC, сalpain substrate

Cat. #	Quantity	Price	Lead time	Buy this product
4454-100mg	100 mg	$145	in stock
4454-1g	1 g	$695	in stock

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H-Met-AMC (L-methionine-7-amido-4-methylcoumarin) is a fluorogenic substrate for methionine aminopeptidase 2 (MetAP2) (Km=310 µM) and aminopeptidase N (Km=377 µM). This substrate is a useful tool for inhibitor screening and kinetic analysis.

H-Met-AMC has an excitation peak at 341 nm and emission at 441 nm. The following excitation/emission can also be used: 355,375/440,450.

Structure of H-Met-AMC, сalpain substrate

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Absorption and emission spectra of сalpain substrate

General properties

Appearance:	off-white crystals
Molecular weight:	306.39
CAS number:	94367-34-7, 94367-35-8 (trifluoroacetate)
Molecular formula:	C₁₅H₁₈N₂O₃S
Solubility:	Soluble in DMF, DMSO, acetonitrile, ethyl acetate. Slightly soluble in chloroform. Insoluble in water, diethyl ether
Quality control:	NMR ¹H and HPLC-MS (95+%)
Storage conditions:	24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate.
MSDS:	Download
	Product specifications

Spectral properties

Excitation/absorption maximum, nm:	341
Emission maximum, nm:	441

This Product is offered and sold for research purposes only. It has not been tested for safety and efficacy in food, drug, medical device, cosmetic, commercial or any other use. Supply does not express or imply authorization to use for any other purpose, including, without limitation, in vitro diagnostic purposes, in the manufacture of food or pharmaceutical products, in medical devices or in cosmetic products.