Cyanine5.5 NHS ester

Cat. # Quantity Price Lead time

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17020 1 mg 110.00$ in stock
27020 5 mg 210.00$ 5 days
47020 25 mg 410.00$ 5 days
57020 50 mg 695.00$ in stock
67020 100 mg 1190.00$ in stock

Cyanine5.5 NHS ester is a reactive dye for the labeling of amino-groups in peptides, proteins, and oligonucleotides, an analog of Cy5.5® NHS ester.

Cy5.5 is a far-red (and near-infrared) emitting dye which is ideal for fluorescence measurements where background fluorescence is a concern. It is also suitable for in vivo NIR imaging experiments.

This reagent can replace NHS esters of Cy5.5®, Alexa Fluor 680, and DyLight 680.

Cy5.5 absorbance and emission spectra

General properties

Appearance: dark blue powder
Molecular weight: 716.31
Molecular formula: C44H46ClN3O4
Solubility: soluble in organic solvents (DMSO, DMF, dichloromethane), low solubility in water
Quality control: NMR 1H (95%) and 13C, TLC, functional testing
Storage conditions: Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
MSDS: Download

Spectral properties

Excitation maximum, nm: 673
Extinction coefficient at excitation maximum, Lmol-1cm-1: 209000
Emission maximum, nm: 707
Fluorescence quantum yield: 0.2

Product citations

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  2. Al-Hilal, T.A.; Alam, F.; Park, J.W.; Kim, K.; Kwon, I.C.; Ryu, G.H.; Byun, Y. Journal of Controlled Release. Prevention effect of orally active heparin conjugate on cancer-associated thrombosis, 2014, 195, 155-161. doi: 10.1016/j.jconrel.2014.05.027
  3. Graen, T.M.D.; Hoefling, M.; Grubmüller, H. Journal of Chemical Theory and Computation. AMBER-DYES: Characterization of Charge Fluctuations and Force Field Parameterization of Fluorescent Dyes for Molecular Dynamics Simulations, 2014, 10(12), 5505-5512. doi: 10.1021/ct500869p
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  8. Zou, Y.; Li, F.; Hou, W.; Sampath, P.; Zhang, Y.; Thorne, S.H. British Journal of Cancer. Manipulating the expression of chemokine receptors enhances delivery and activity of cytokine-induced killer cells, 2014, 110(8), 1992-1999. doi: 10.1038/bjc.2014.140
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  11. Wang, C.; Ravi, S.; Garapati, U.S.; Das, M.; Howell, M.; Mallela, J.; Alwarappan, S.; Mohapatra, S.S.; Mohapatra, S. Journal of Materials Chemistry B. Multifunctional chitosan magnetic-graphene (CMG) nanoparticles: a theranostic platform for tumor-targeted co-delivery of drugs, genes and MRI contrast agents, 2013, 1(35), 4396-4396. doi: 10.1039/c3tb20452a
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  14. Adulnirath, A.; Chung, S.W.; Park, J.; Hwang, S.R.; Kim, J.-Y.; Yang, V.C.; Kim, S.Y.; Moon, H.T.; Byun, Y. Journal of Controlled Release. Cyclic RGDyk-conjugated LMWH-taurocholate derivative as a targeting angiogenesis inhibitor, 2012, 164(1), 8-16. doi: 10.1016/j.jconrel.2012.10.001
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