PROTAC in Applications
Proteolysis targeting chimeras (PROTACs) are cell-permeable heterobifunctional molecules that can remove specific proteins from the cell. One end of such molecule contains a ligand to bind to the target, and the second end recruits the E3 ligase complex. Close proximity results in substrate polyubiquitination and subsequent protein degradation by cellular proteasome.
Thalidomide-carboxylic acid
Thalidomide-containing building block with carboxylic acid functionality for convenient PROTAC molecule assembly by attachment amino-functionalized linkers and ligands to thalidomide via 4-O-position.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 4169-100mg | 100 mg | $160 | in stock | |
| 4169-500mg | 500 mg |
$510
|
in stock | |
| 4169-1g | 1 g |
$740
|
in stock |
Thalidomide-O-PEG2-azide
Thalidomide-containing building block with PEG2-linker and azide function group for conjugation with alkyne-functionalized linkers and target protein ligands through click chemistry reactions.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 4154-25mg | 25 mg | $189 | in stock | |
| 4154-100mg | 100 mg |
$489
|
in stock |
Thalidomide-O-PEG2-carboxylic acid
Thalidomide-containing building block with PEG2-linker and carboxylic group for conjugation with amino-functionalized linkers and target protein ligands.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 4192-25mg | 25 mg | $148 | in stock | |
| 4192-100mg | 100 mg |
$480
|
in stock |
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