Alkynes in Reactive groups

Terminal alkynes react with azides in a copper-catalyzed process called copper-catalyzed alkyne azide cycloaddition (CuAAC). The reaction is a useful method for the conjugation and fluorescent labeling of biomolecules.

Click chemistry (CuAAc) reaction scheme

Lumiprobe offers a range of terminal alkyne derivatives, including fluorescent dye alkynes, and linkers with alkyne group.

1-Ethynyl pyrene

Pyrene is a polyaromatic hydrocarbon containing four fused rings. This reagent contains a terminal alkyne group for click chemistry and other reactions, such as Sonogashira coupling.
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Cat. # Quantity Price Lead time
515B0 50 mg $50 in stock
615B0 100 mg $64 in stock
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3-Ethynylperylene

Alkyne derivative of ultra-bright and photostable perylene fluorophore.
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Cat. # Quantity Price Lead time
555B0 50 mg $100 in stock
655B0 100 mg $160 in stock
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Ac4GalNAl (N-(4-pentynoyl)-galactosamine-tetraacylated)

An alkyne-functionalized monosaccharide for metabolic labeling and studying the cellular trafficking of labeled proteins and proteomic analysis.
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Cat. # Quantity Price Lead time
4037-5mg 5 mg $129 in stock
4037-25mg 25 mg $240 in stock
4037-100mg 100 mg $630 in stock
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Ac4GlcNAl (N-4-pentynoyl-glucosamine-tetraacylated)

An alkyne-functionalized monosaccharide for metabolic labeling and studying the cellular trafficking of labeled proteins and proteomic analysis.
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Cat. # Quantity Price Lead time
4130-5mg 5 mg $129 12 days
4130-25mg 25 mg $240 7 days
4130-100mg 100 mg $630 7 days
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Ac4ManNAl (N-(4-pentynoyl)-mannosamine-tetraacylated)

An alkyne-functionalized monosaccharide for metabolic labeling and studying the cellular trafficking of labeled proteins and proteomic analysis.
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Cat. # Quantity Price Lead time
3431-5mg 5 mg $129 in stock
3431-25mg 25 mg $240 in stock
3431-100mg 100 mg $630 in stock
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AF 430 alkyne

Alkyne derivative of yellow-green fluorescent dye AF 430 for copper-catalyzed click reaction with azides.
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Cat. # Quantity Price Lead time
A08B0 1 mg $125 in stock
B08B0 5 mg $325 in stock
C08B0 10 mg $480 in stock
D08B0 25 mg $950 in stock
E08B0 50 mg $1625 in stock
F08B0 100 mg $2090 in stock
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AF 488 alkyne

Alkyne derivative of AF 488 dye for copper-catalyzed cycloaddition to azides. Pure 5-isomer.
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Cat. # Quantity Price Lead time
A18B0 1 mg $125 5 days
B18B0 5 mg $325 in stock
D18B0 25 mg $950 in stock
E18B0 50 mg $1625 in stock
F18B0 100 mg $2090 in stock
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AF 568 alkyne

AF 568 derivative designed for fluorescence microscopy and flow cytometry. Pure 5-isomer.
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Cat. # Quantity Price Lead time
A48B0 1 mg $140 in stock
B48B0 5 mg $450 in stock
C48B0 10 mg $585 in stock
D48B0 25 mg $1460 in stock
E48B0 50 mg $1890 in stock
F48B0 100 mg $2990 in stock
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Alkyne amidite, hydroxyprolinol

Acetylenic amidite for the incorporation of acetylene groups into oligos.
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Cat. # Quantity Price Lead time
21360 250 mg $110 in stock
41360 1 g $390 in stock
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Alkyne CPG modifier 500

Solid support for the synthesis of 3'-modified oligonucleotides with alkyne group for Click Chemistry.
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Cat. # Quantity Price Lead time
12860 100 mg $60 in stock
22860 250 mg $120 in stock
32860 500 mg $230 in stock
42860 1 g $380 in stock
52860 5 g $1450 in stock
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Alkyne dT phosphoramidite

Phosphoramidite modifier for the synthesis of oligonucleotides containing alkyne modification in the middle of the chain.
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Cat. # Quantity Price Lead time
1897-100mg 100 mg $330 in stock
1897-1g 1 g $2590 in stock
1897-5g 5 g $9900 in stock
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Alkyne hydrazide

Bifunctional reagent containing alkyne group and hydrazide function. It reacts with aldehydes and ketones. Alkyne group can then be coupled with various azides via CuAAC reaction.
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Cat. # Quantity Price Lead time
41770 25 mg $110 in stock
51770 50 mg $195 in stock
61770 100 mg $290 in stock
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Alkyne maleimide

Maleimide reagent for the attachment of alkyne functional group to proteins, peptides, and other molecules bearing SH (thiol) groups, including cysteine residues.
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Cat. # Quantity Price Lead time
41780 25 mg $95 in stock
51780 50 mg $175 in stock
61780 100 mg $200 in stock
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Alkyne phosphoramidite, 5'-terminal

Alkyne phosphoramidite for the synthesis of oligonucleotides ready for click chemistry.
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Cat. # Quantity Price Lead time
22260 250 mg $110 in stock
32260 500 mg $210 in stock
42260 1 g $350 in stock
62260 5 g $1290 in stock
82260 10 g please inquire in stock
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Alkyne-PEG2-amine

Diethyleneglycol (PEG2) based bifunctional linker containing amine and alkyne functional groups.
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Cat. # Quantity Price Lead time
2065-1g 1 g $120 in stock
2065-5g 5 g $350 in stock
2065-25g 25 g please inquire in stock
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Alkyne-PEG2-carboxylic acid

Bifunctional diethyleneglycol linker with terminal alkyne and carboxylic acid moieties.
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Cat. # Quantity Price Lead time
2155-1g 1 g $380 in stock
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Alkyne-PEG2-iodide

Bifunctional reactive crosslinker containing terminal alkyne group for click chemistry or Sonogashira coupling, and reactive alkyl iodide group.
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Cat. # Quantity Price Lead time
2136-1g 1 g $450 in stock
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Alkyne-PEG2-NHS ester

Bifunctional hydrophilic linker with NHS ester and terminal alkyne functional group based on diethyleneglycol (PEG2).
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Cat. # Quantity Price Lead time
2219-1g 1 g $450 in stock
2219-5g 5 g $980 in stock
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Alkyne-PEG3-amine

Alkyne-PEG3-amine is a medium-length heterobifunctional linker for conjugation.
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Cat. # Quantity Price Lead time
425-1g 1 g $195 in stock
425-5g 5 g $580 in stock
425-25g 25 g please inquire in stock
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Alkyne-PEG3-carboxylic acid

Bifunctional triethyleneglycol linker with terminal alkyne and carboxylic acid moieties.
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Cat. # Quantity Price Lead time
1743-1g 1 g $490 in stock
1743-5g 5 g $980 in stock
1743-25g 25 g please inquire in stock
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Alkyne-PEG3-iodide

PEG3 with alkyne and iodide functional groups, a reactive and hydrophilic linker for alkylation and click chemistry.
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Cat. # Quantity Price Lead time
2193-1g 1 g $490 in stock
2193-5g 5 g $1150 in stock
2193-25g 25 g please inquire in stock
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Alkyne-PEG3-maleimide

Bifunctional spacer with alkyne and maleimide groups for conjugation of biomolecules.
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Cat. # Quantity Price Lead time
2344-100mg 100 mg $140 in stock
2344-1g 1 g $530 in stock
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Alkyne-PEG3-NHS ester

Bifunctional hydrophilic linker with NHS ester and terminal alkyne functional group based on triethyleneglycol (PEG3).
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Cat. # Quantity Price Lead time
2298-1g 1 g $490 in stock
2298-5g 5 g $980 in stock
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Alkyne-PEG3-OH

Alkyne-PEG3-OH is a triethyleneglycol based bifunctional linker with a hydroxyl group and an alkyne fragment.
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Cat. # Quantity Price Lead time
418-1g 1 g $95 in stock
418-5g 5 g $280 in stock
418-25g 25 g please inquire in stock
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Alkyne-PEG4-amine

A bifunctional linker molecule containing both terminal alkyne moiety for click chemistry, and amine group. Contains a long hydrophilic PEG4 arm.
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Cat. # Quantity Price Lead time
2025-100mg 100 mg $95 in stock
2025-1g 1 g $390 in stock
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Alkyne-PEG4-carboxylic acid

Bifunctional tetraethyleneglycol linker with terminal alkyne and carboxylic acid moieties.
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Cat. # Quantity Price Lead time
2187-1g 1 g $380 in stock
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Alkyne-PEG4-iodide

Bifunctional reactive PEG4-based crosslinker containing terminal alkyne group for click chemistry or Sonogashira coupling and reactive alkyl iodide group.
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Cat. # Quantity Price Lead time
2188-1g 1 g $450 in stock
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Alkyne-PEG4-maleimide

Water soluble, heterobifunctional hydrophilic linker with a length of 14 Å, containing maleimide for thiol labeling, and alkyne for click chemistry. An ideal reagent to attach an alkyne moiety to a protein.
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Cat. # Quantity Price Lead time
2002-100mg 100 mg $150 in stock
2002-1g 1 g $590 in stock
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Alkyne-PEG4-NHS ester

Bifunctional hydrophilic linker with NHS ester and terminal alkyne functional group based on tetraethyleneglycol (PEG4).
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Cat. # Quantity Price Lead time
2409-100mg 100 mg $250 in stock
2409-1g 1 g $790 in stock
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Alkyne-PEG4-phosphoramidite

Alkyne phosphoramidite for conjugation of oligonucleotides with biomolecules.
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Cat. # Quantity Price Lead time
2779-100mg 100 mg $390 in stock
2779-250mg 250 mg $680 in stock
2779-1g 1 g $1640 in stock
2779-5g 5 g please inquire in stock
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BDP 558/568 alkyne

BDP 558/568 is a borondipyrromethene dye for Cyanine3-channel. This product is a terminal alkyne derivative for copper-catalyzed click chemistry.
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Cat. # Quantity Price Lead time
A74B0 1 mg $125 in stock
B74B0 5 mg $260 in stock
C74B0 10 mg $325 in stock
D74B0 25 mg $510 in stock
E74B0 50 mg $895 in stock
F74B0 100 mg $1490 in stock
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BDP 581/591 alkyne

BDP 581/591 is a borondipyrromethene fluorophore useful for fluorescence polarization assays, microscopy, and two-photon experiments. This alkyne is a derivative for copper-catalyzed click chemistry.
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Cat. # Quantity Price Lead time
A64B0 1 mg $125 in stock
B64B0 5 mg $260 in stock
C64B0 10 mg $325 in stock
D64B0 25 mg $510 in stock
E64B0 50 mg $895 in stock
F64B0 100 mg $1490 in stock
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BDP 630/650 alkyne

Alkyne dye for copper-catalyzed click chemistry, containing borondipyrromethene fluorophore BDP 630/650 for the red channel.
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Cat. # Quantity Price Lead time
A54B0 1 mg $125 in stock
B54B0 5 mg $260 in stock
C54B0 10 mg $325 in stock
D54B0 25 mg $510 in stock
E54B0 50 mg $895 in stock
F54B0 100 mg $1490 in stock
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BDP 650/665 alkyne

BDP 650/665 is a bright borondipyrromethene red-emitting dye. The terminal ethynyl group of BDP 650/665 alkyne can be easily conjugated with various azides using a copper-catalyzed click reaction.
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Cat. # Quantity Price Lead time
A84B0 1 mg $125 in stock
B84B0 5 mg $260 in stock
C84B0 10 mg $325 in stock
D84B0 25 mg $510 in stock
E84B0 50 mg $895 in stock
F84B0 100 mg $1490 in stock
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BDP FL alkyne

Borondipyrromethene dye alkyne for click chemistry. Bright and photostable dye for FAM channel.
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Cat. # Quantity Price Lead time
A14B0 1 mg $125 in stock
B14B0 5 mg $260 in stock
C14B0 10 mg $325 in stock
D14B0 25 mg $510 in stock
E14B0 50 mg $895 in stock
F14B0 100 mg $1490 in stock
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BDP R6G alkyne

Terminal alkyne derivative of BDP R6G dye for сlick chemistry. BDP R6G is a borondipyrromethene dye whose absorption and emission spectra are similar to R6G (rhodamine 6G).
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Cat. # Quantity Price Lead time
A44B0 1 mg $125 in stock
B44B0 5 mg $260 in stock
C44B0 10 mg $325 in stock
D44B0 25 mg $510 in stock
E44B0 50 mg $895 in stock
F44B0 100 mg $1490 in stock
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BDP TMR alkyne

Borondipyrromethene dye for TAMRA channel, with alkyne group for copper-catalyzed click chemistry.
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Cat. # Quantity Price Lead time
A24B0 1 mg $125 in stock
B24B0 5 mg $260 in stock
C24B0 10 mg $325 in stock
D24B0 25 mg $510 in stock
E24B0 50 mg $895 in stock
F24B0 100 mg $1490 in stock
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BDP TR alkyne

BDP TR is a fluorophore for ROX channel. This borondipyrromethene dye is very bright, and resistant to oxidation.
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Cat. # Quantity Price Lead time
A34B0 1 mg $125 in stock
B34B0 5 mg $260 in stock
C34B0 10 mg $325 in stock
D34B0 25 mg $510 in stock
E34B0 50 mg $895 in stock
F34B0 100 mg $1490 in stock
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Biotin alkyne

Biotin alkyne is a reactive affinity label which can be attached to biomolecules via click reaction.
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Cat. # Quantity Price Lead time
C37B0 10 mg $135 in stock
D37B0 25 mg $325 in stock
E37B0 50 mg $575 in stock
F37B0 100 mg $1150 in stock
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Biotin-PEG2-alkyne

Biotin alkyne is a reagent for click chemistry labeling with biotin, an affinity probe to streptavidin.
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Cat. # Quantity Price Lead time
2546-50mg 50 mg $125 in stock
2546-100mg 100 mg $185 in stock
2546-1g 1 g $990 in stock
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Biotin-PEG4-alkyne

Biotin alkyne is a reagent for click chemistry labeling with biotin, an affinity probe to streptavidin.
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Cat. # Quantity Price Lead time
2615-50mg 50 mg $125 in stock
2615-100mg 100 mg $185 in stock
2615-1g 1 g $990 in stock
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Cyanine3 alkyne

Cyanine3 alkyne is a fluorescent dye alkyne for сlick сhemistry.
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Cat. # Quantity Price Lead time
A10B0 1 mg $125 in stock
B10B0 5 mg $260 in stock
C10B0 10 mg $325 in stock
D10B0 25 mg $510 in stock
E10B0 50 mg $895 in stock
F10B0 100 mg $1490 in stock
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Cyanine5 alkyne

Cyanine5 alkyne is an alkyne dye for click chemistry labeling of biomolecules.
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Cat. # Quantity Price Lead time
A30B0 1 mg $125 in stock
B30B0 5 mg $260 in stock
C30B0 10 mg $325 in stock
D30B0 25 mg $510 in stock
E30B0 50 mg $895 in stock
F30B0 100 mg $1490 in stock
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Cyanine5.5 alkyne

Cyanine5.5 alkyne is a NIR (near infrared) dye azide for copper-catalyzed сlick сhemistry.
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Cat. # Quantity Price Lead time
A70B0 1 mg $125 in stock
B70B0 5 mg $260 in stock
C70B0 10 mg $325 in stock
D70B0 25 mg $510 in stock
E70B0 50 mg $895 in stock
F70B0 100 mg $1490 in stock
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Cyanine7 alkyne

Cyanine7 alkyne is a near infrared (NIR) dye alkyne for click chemistry.
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Cat. # Quantity Price Lead time
A50B0 1 mg $125 in stock
B50B0 5 mg $260 in stock
C50B0 10 mg $325 in stock
D50B0 25 mg $510 in stock
E50B0 50 mg $895 in stock
F50B0 100 mg $1490 in stock
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Cyanine7.5 alkyne

Reactive near infrared (NIR) dye for click chemistry containing a terminal alkyne group.
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Cat. # Quantity Price Lead time
A60B0 1 mg $125 in stock
B60B0 5 mg $260 in stock
C60B0 10 mg $325 in stock
D60B0 25 mg $510 in stock
E60B0 50 mg $895 in stock
F60B0 100 mg $1490 in stock
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EdU (5-Ethynyl-2'-deoxyuridine)

EdU is a nucleoside that is incorporated into replicated DNA by cellular enzymes. After it, DNA contained in the cells can be developed by click chemistry reaction with fluorescent dye azides to reveal cell proliferation.
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Cat. # Quantity Price Lead time
10540 100 mg $120 in stock
20540 250 mg $195 in stock
30540 500 mg $345 in stock
40540 1 g $590 in stock
60540 5 g please inquire in stock
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F-ara-EdU (2’-Deoxy-2’-fluoro-5-ethynyluridine)

F-ara-EdU is a synthetic analog of thymidine used to study de novo DNA synthesis and cell proliferation. It is a less cytotoxic alternative for BrdU and EdU.
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Cat. # Quantity Price Lead time
3438-25mg 25 mg $375 in stock
3438-100mg 100 mg $825 in stock
3438-500mg 500 mg please inquire in stock
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FAM alkyne, 5-isomer

FAM alkyne, 5-isomer - an alkyne derivative of fluorescein dye for click chemistry.
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Cat. # Quantity Price Lead time
B41B0 5 mg $100 in stock
C41B0 10 mg $150 in stock
D41B0 25 mg $295 in stock
E41B0 50 mg $450 in stock
F41B0 100 mg $780 in stock
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FAM alkyne, 6-isomer

Fluorescein dye alkyne for click chemistry conjugation, pure 6-isomer.
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Cat. # Quantity Price Lead time
B51B0 5 mg $100 in stock
C51B0 10 mg $150 in stock
D51B0 25 mg $295 in stock
E51B0 50 mg $450 in stock
F51B0 100 mg $780 in stock
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Hexynoic acid NHS ester

Hexynoic acid NHS ester for the labeling of biomolecules with alkyne group for copper-catalyzed click chemistry.
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Cat. # Quantity Price Lead time
41720 25 mg $95 in stock
51720 50 mg $180 in stock
61720 100 mg $290 in stock
91720 1 g please inquire in stock
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Hexynoic acid STP ester

Alkyne activated ester for the modification of amine groups. STP ester group is an excellent alternative to NHS ester functionality.
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Cat. # Quantity Price Lead time
569-25mg 25 mg $95 in stock
569-100mg 100 mg $185 in stock
569-500mg 500 mg $850 in stock
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HPG (L-Homopropargylglycine)

Noncanonical amino acid analog of methionine with a terminal alkyne moiety for nascent protein synthesis detection.
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Cat. # Quantity Price Lead time
3313-25mg 25 mg $129 in stock
3313-100mg 100 mg $249 in stock
3313-1g 1 g please inquire in stock
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JOE alkyne, 6-isomer

JOE dye alkyne derivative for copper-catalyzed click chemistry reaction with azides. JOE dye is widely used for nucleic acid labeling.
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Cat. # Quantity Price Lead time
A21B0 1 mg $110 in stock
B21B0 5 mg $210 in stock
C21B0 10 mg $310 in stock
D21B0 25 mg $410 in stock
E21B0 50 mg $695 in stock
F21B0 100 mg $1190 in stock
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R6G alkyne, 6-isomer

R6G (rhodamine 6G) terminal alkyne for copper-catalyzed click chemistry reaction with azides. Pure 6-isomer of the dye.
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Cat. # Quantity Price Lead time
A52B0 1 mg $110 in stock
B52B0 5 mg $210 in stock
C52B0 10 mg $310 in stock
D52B0 25 mg $410 in stock
E52B0 50 mg $695 in stock
F52B0 100 mg $1190 in stock
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ROX alkyne, 5-isomer

An alkyne derivative of bright red-emitting dye ROX (Rhodamine X, Rhodamine 101) for copper-catalyzed click chemistry bioconjugation. Pure 5-isomer.
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Cat. # Quantity Price Lead time
A12B0 1 mg $110 in stock
B12B0 5 mg $165 in stock
C12B0 10 mg $210 in stock
D12B0 25 mg $285 in stock
E12B0 50 mg $495 in stock
F12B0 100 mg $1190 in stock
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ROX alkyne, 6-isomer

An alkyne derivative of bright red-emitting dye ROX (Rhodamine X, Rhodamine 101) for copper-catalyzed click chemistry bioconjugation. Pure 6-isomer.
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Cat. # Quantity Price Lead time
A22B0 1 mg $110 in stock
B22B0 5 mg $165 in stock
C22B0 10 mg $210 in stock
D22B0 25 mg $285 in stock
E22B0 50 mg $495 in stock
F22B0 100 mg $880 in stock
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sulfo-Cyanine3 alkyne

A water-soluble dye alkyne for copper-catalyzed click chemistry. The fluorophore sulfo-Cyanine3 is a bright and photostable dye for the Cy3® channel.
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Cat. # Quantity Price Lead time
A13B0 1 mg $125 in stock
B13B0 5 mg $325 in stock
C13B0 10 mg $470 in stock
D13B0 25 mg $850 in stock
E13B0 50 mg $1490 in stock
F13B0 100 mg $1990 in stock
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sulfo-Cyanine3.5 alkyne

Alkyne derivative of water-soluble sulfo-Cyanine3.5 dye for copper-catalyzed click chemistry.
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Cat. # Quantity Price Lead time
A23B0 1 mg $125 in stock
B23B0 5 mg $260 in stock
C23B0 10 mg $325 in stock
D23B0 25 mg $510 in stock
E23B0 50 mg $895 in stock
F23B0 100 mg $1490 in stock
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sulfo-Cyanine5 alkyne

sulfo-Cyanine5 is a water-soluble Cyanine5 dye alkyne for click chemistry.
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Cat. # Quantity Price Lead time
A33B0 1 mg $125 in stock
B33B0 5 mg $290 in stock
C33B0 10 mg $470 in stock
D33B0 25 mg $850 in stock
E33B0 50 mg $1490 in stock
F33B0 100 mg $1990 in stock
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sulfo-Cyanine5.5 alkyne

Alkyne functionalized, water soluble far red/near infrared emitting fluorophore sulfo-Cyanine5.5.
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Cat. # Quantity Price Lead time
A73B0 1 mg $110 in stock
B73B0 5 mg $325 in stock
C73B0 10 mg $470 in stock
D73B0 25 mg $850 in stock
E73B0 50 mg $1490 in stock
F73B0 100 mg $2590 in stock
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sulfo-Cyanine7 alkyne

A sulfonated near-infrared dye alkyne for copper-catalyzed cycloaddition with azides.
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Cat. # Quantity Price Lead time
A53B0 1 mg $125 in stock
B53B0 5 mg $325 in stock
C53B0 10 mg $470 in stock
D53B0 25 mg $850 in stock
E53B0 50 mg $1490 in stock
F53B0 100 mg $1990 in stock
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sulfo-Cyanine7.5 alkyne

sulfo-Cyanine7.5 is a near-infrared fluorophore similar to Indocyanine Green (ICG) but possesses higher fluorescence quantum yield. This is an alkyne for copper-catalyzed click chemistry.
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Cat. # Quantity Price Lead time
A63B0 1 mg $125 in stock
B63B0 5 mg $325 in stock
C63B0 10 mg $470 in stock
D63B0 25 mg $850 in stock
E63B0 50 mg $1490 in stock
F63B0 100 mg $1990 in stock
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TAMRA alkyne, 5-isomer

Alkyne derivative of TAMRA dye, pure 5-isomer for сopper-catalyzed сlick chemistry.
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Cat. # Quantity Price Lead time
B71B0 5 mg $260 in stock
C71B0 10 mg $325 in stock
D71B0 25 mg $410 in stock
E71B0 50 mg $695 in stock
F71B0 100 mg $890 in stock
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TAMRA alkyne, 6-isomer

Terminal alkyne for copper-catalyzed click chemistry. Tetramethylrhodamine (TAMRA) is a rhodamine dye which is popular in qPCR and other applications. TAMRA is a also a FRET acceptor for FAM.
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Cat. # Quantity Price Lead time
B81B0 5 mg $260 in stock
C81B0 10 mg $325 in stock
D81B0 25 mg $410 in stock
E81B0 50 mg $695 in stock
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