THPTA ligand

Cat. # Quantity Price Lead time
F4050 100 mg $65 in stock
H4050 500 mg $199 in stock
I4050 1 g $369 in stock
K4050 5 g $1568 in stock
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THPTA ligand (tris-hydroxypropyltriazolylmethylamine) is a triazole ligand for water-based copper-catalyzed click chemistry reactions. This reagent is very well water-soluble. It is especially useful for click chemistry labeling and conjugation of proteins, including antibodies, when organic co-solvents are undesirable.

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General properties

Appearance: off white solid
Molecular weight: 434.5
CAS number: 760952-88-3
Molecular formula: C18H30N10O3
IUPAC name: 3-[4-[[bis[[1-(3-hydroxypropyl)triazol-4-yl]methyl]amino]methyl]triazol-1-yl]propan-1-ol
Solubility: good in water, DMF, DMSO
Quality control: NMR 1H, HPLC-MS (95%)
Storage conditions: Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks.
MSDS: Download
Product specifications

Product citations

  1. Cardenas, A.J.; Thomas, K.S.; Broden, M.W.; Ferraro, N.J.; John, C.M.; Pires, M.M.; Jarvis, G.A.; Criss, A.K. Neisseria gonorrhoeaescavenges host sialic acid for Siglec-mediated, complement-independent suppression of neutrophil activation. bioRxiv, 2024, preprint. doi: 10.1101/2024.01.17.576097
  2. Slapak, E.J.; el Mandili, M.; Ten Brink, M.S.; Kros, A.; Bijlsma, M.F.; Spek, C.A. CAPN2-responsive mesoporous silica nanoparticles: A promising nanocarrier for targeted therapy of pancreatic cancer. Cancer Letters, 2024, 590, 216845. doi: 10.1016/j.canlet.2024.216845
  3. Narum, S.; Deal, B.; Ogasawara, H.; Mancuso, J. N.; Zhang, J.; Salaita, K. An Endosomal Escape Trojan Horse Platform to Improve Cytosolic Delivery of Nucleic Acids. ACS Nano, 2024, 18(8), 6186–6201. doi: 10.1021/acsnano.3c09027
  4. Slapak, E.J.; el Mandili, M.; Brink, M.S.T.; Kros, A.; Bijlsma, M.F.; Spek, C.A. Preclinical Assessment of ADAM9-Responsive Mesoporous Silica Nanoparticles for the Treatment of Pancreatic Cancer. International Journal of Molecular Sciences, 2023, 24(13), 10704. doi: 10.3390/ijms241310704
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