MGB CPG 1000

Cat. #	Quantity	Price	Lead time	Buy this product
3439-100mg	100 mg	$195	in stock
3439-1g	1 g	$1600	in stock

Bulk inquiry

Found better price? Let us know and we will propose the way forward!

Dihydropyrroloindole carboxylate (DPI) represents the class minor groove binders (MGB) compounds capable of site-specifically incorporation into the DNA minor groove.

MGB controlled pore glass (CPG) is used as a support for the direct synthesis of oligonucleotides bearing pyrrole subunits arranged along an artificial peptide backbone useful for efficient nucleic acid duplex stabilizing due to higher melting temperatures (Tm) mediated base-stacking interactions in MGB probes.

Designs of oligonucleotides with MGB moiety at the 3'-terminus can be used for hybridization-based assays utilizing stable complexes formed by oligonucleotides with the complementary sequences, e.g., DNA probes in quantitative PCR-based assays.

Usage

Oxidation: preferably 0.5 M CSO in acetonitrile (3 min), when using iodine, iodination products are formed.

Deblocking: standard conditions using CSO as oxidizer, NH₄OH/EtOH 3:1 (v/v) 24 hours at 55 °C using iodine oxidizer.

Download in
ChemDraw format

Customers also purchased with this product

PreciseGreen dsDNA Quantification Reagent, 200×

PreciseGreen is a dye for precise fluorescence-based quantification of dsDNA in the presence of RNA, ssDNA, and other impurities. The dye exhibits bright fluorescence in the fluorescein channel, which provides a linear response to DNA concentration within the range of low pg/mL to high ng/mL.

DusQ 1 NHS ester

Functionalized DusQ 1 quencher derivative with quenching range from 480 - 580 nm for labeling of amine-containing molecules.

DusQ 21 CPG 500

DusQ 21 is a quencher for dyes in red part of the spectrum, including Cyanine5 and Cyanine5.5.

Add this product to your cart and
get free express delivery

General properties

Appearance:	off white beads
Storage conditions:	24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate.
MSDS:	Download
	Product specifications

Oligo synthesis details

Pore size, Å:	1000
Typical loading, umol/g:	>15

This Product is offered and sold for research purposes only. It has not been tested for safety and efficacy in food, drug, medical device, cosmetic, commercial or any other use. Supply does not express or imply authorization to use for any other purpose, including, without limitation, in vitro diagnostic purposes, in the manufacture of food or pharmaceutical products, in medical devices or in cosmetic products.

Your item has been added. View your cart or proceed to checkout