HPG (L-Homopropargylglycine)

Alkynes Click chemistry
Cat. # Quantity Price Lead time
3313-25mg 25 mg $129 in stock
3313-100mg 100 mg $249 in stock
3313-1g 1 g please inquire in stock
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L-Homopropargylglycine (HPG) is a noncanonical amino acid analog of methionine that contains a terminal alkyne moiety. HPG-labeling is a fast, sensitive, non-toxic, and non-radioactive alternative to the traditional technique for detecting nascent protein synthesis.

HPG is the cell-permeable compound randomly incorporated into synthesizing protein instead of methionine during translation. The resulting alkyne-labeled full-length proteins can be detected via copper-catalyzed click reaction with fluorescent or biotin-labeled azides and used for subsequent microscopic imaging or purification tasks.

HPG (L-Homopropargylglycine), 3313-100mg
HPG (L-Homopropargylglycine), 3313-100mg
HPG (L-Homopropargylglycine), 3313-100mg
Structure of L-Homopropargylglycine hydrochloride
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General properties

Appearance: off-white solid
Molecular weight: 163.60
CAS number: 942518-19-6
Molecular formula: C6H10ClNO2
Solubility: good in water (max. 125 mg/mL) and DMSO (max. 250 mg/mL)
Quality control: NMR 1H and HPLC-MS (95+%)
Storage conditions: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate.
MSDS: Download
Product specifications

Product citations

  1. Baleva, M.V.; Piunova, U.; Chicherin, I.; Vasilev, R.; Levitskii, S.; Kamenski, P. Mitochondrial Protein SLIRP Affects Biosynthesis of Cytochrome c Oxidase Subunits in HEK293T Cells. International Journal of Molecular Sciences, 2024, 25(1), 93. doi: 10.3390/ijms25010093
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