Alkyne amidite, hydroxyprolinol
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 21360 | 250 mg | $110 | in stock | |
| 41360 | 1 g | $390 | in stock |
Phosphoramidite for the synthesis of alkyne-modified oligonucleotides. Oligonucleotides can be used for сlick сhemistry modification (see the protocol).
Diluent for this amidite is acetonitrile, 5 min coupling time is recommended. Standard deprotection conditions can be used for oligonucleotides.
Oligonucleotides can be purified by HPLC or cartridges due to the presence of dimethoxytrityl group, as well as by PAGE.
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Solid support for the synthesis of 3'-modified oligonucleotides with alkyne group for Click Chemistry.General properties
| Appearance: | colorless semisolid |
| Molecular weight: | 713.84 |
| CAS number: | 1357289-02-1 |
| Molecular formula: | C41H52N3O6P |
| IUPAC name: | Phosphoramidous acid, N,N-bis(1-methylethyl)-, (3R,5S)-5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-1-(1-oxo-5-hexyn-1-yl)-3-pyrrolidinyl 2-cyanoethyl ester |
| Solubility: | good in acetonitrile and dichloromethane |
| Quality control: | NMR 1H and 31P, HPLC-MS (95 %) |
| Storage conditions: | Storage: 12 months after receival at -20°C. Transportation: at room temperature for up to 3 weeks. Desiccate. |
| MSDS: | Download |
| Product specifications |
Oligo synthesis details
| Diluent: | acetonitrile |
| Coupling conditions: | standard coupling, identical to normal nucleobases |
| Deprotection conditions: | identical to protected nucleobases |
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