Sulfo-Cyanine5.5 amine

Amines sulfo-Cyanine5.5
Cat. # Quantity Price Lead time
173C0 1 mg $110.00 in stock
273C0 5 mg $290.00 in stock
473C0 25 mg $690.00 in stock
573C0 50 mg $1190.00 in stock
673C0 100 mg $1850.00 in stock
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Sulfo-Cyanine5.5 is a water soluble cyanine dye for far red / NIR applications such as in vivo imaging. The dye possesses four sulfonate groups that render it highly hydrophilic and water soluble. As well as other cyanines, sulfo-Cyanine5.5 has an outstanding extinction coefficient that makes it a bright fluorescent label for the far red region.

This is an amine-containing fluorescent dye. The amine group is separated from the fluorophore by a relatively long linker that facilitates conjugation. The aliphatic primary amine group can be coupled with various electrophiles (activated esters, epoxides, etc), and also be used in enzymatic transamination labeling.

Sulfo-Cyanine5.5 amine
Sulfo-Cyanine5.5 amine
Sulfo-Cyanine5.5 amine
Structure of sulfo-Cyanine5.5 amine
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Absorption and emission spectra of sulfo-Cyanine5.5 fluorophore

Absorption and emission spectra of sulfo-Cyanine5.5 fluorophore

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TAMRA amine, 5-isomer

TAMRA (tetramethylrhodamine) dye, pure 5-isomer, with an amine group for the conjugation with electrophilic reagents (NHS esters, epoxides, etc).
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General properties

Appearance: dark blue solid
Molecular weight: 1077.41
CAS number: 2183440-46-0 (potassium salt), 2183440-45-9
Molecular formula: C46H54K2N4O13S4
IUPAC name: (E)-4-[(2E,4E)-5-{5-[6-(6-Aminohexylamino)-6-oxohexyl]-3,3-dimethyl-10,12-bis(oxysulfonyl)-5-azatricyclo[7.4.0.02,6]trideca-1,4,6,8,10,12-hexaen-4-yl}-2,4-pentadienylidene]-3,3-dimethyl-5-methyl-5-azatricyclo[7.4.0.02,6]trideca-1,6,8,10,12-pentaene-10,12-disulfonic acid dipotassium salt
Solubility: good in water, DMF, DMSO
Quality control: NMR 1H, HPLC-MS (95%)
Storage conditions: Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
MSDS: Download
Product specifications

Spectral properties

Excitation maximum, nm: 673
ε, L⋅mol−1⋅cm−1: 235000
Emission maximum, nm: 691
CF260: 0.09
CF280: 0.11

Product citations

  1. Khatri, S.; Hansen, J.; Mendes, A.C.; Chronakis, I.S.; Hung, S.-C.; Mellins, E.D.; Astakhova, K. Citrullinated Peptide Epitope Targets Therapeutic Nanoparticles to Human Neutrophils. Bioconjugate Chemistry, 2019, 30(10), 2584–2593. doi: 10.1021/acs.bioconjchem.9b00518
  2. Malinovskaya, Y.; Melnikov, P.; Baklaushev, V.; Gabashvili, A.; Osipova, N.; Mantrov, S.; Ermolenko, Y.; Maksimenko, O.; Gorshkova, M.; Balabanyan, V.; Kreuter, J.; Gelperina, S. Delivery of doxorubicin-loaded PLGA nanoparticles into U87 human glioblastoma cells. International Journal of Pharmaceutics, 2017, 524(1–2), 77–90. doi: 10.1016/j.ijpharm.2017.03.049
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