Click chemistry

Click chemistry / product groups & items in this category
Reagents for Click Chemistry labeling and conjugation, non-fluorescent azides, alkynes.

Non-fluorescent azides

Various non-fluorescent azides for Click Chemistry. Fluorescent azides are listed under Reactive dyes category.
  • AmdU (5-azidomethyl-2'-deoxyuridine)
    Azidomethyldeoxyuridine (AmdU) is an azide containing nucleoside that is incorporated into nascent DNA by cellular polymerases. The azide groups attached to DNA this way can be subsequently modified with alkynes or cycloalkynes via copper-catalyzed or strain promoted Click chemistry.
  • Azide-PEG2-aldehyde
    A linker with an azide group, and an aliphatic aldehyde moiety.
  • Azide-PEG3-OH
    Azide-PEG3-OH is a bifunctional molecule with azide group, primary alcohol, and a hydrophilic linker in between.
  • Azidobutyric acid NHS ester
    Activated ester for azido labeling of peptides and proteins.
  • Biotin-PEG3-Azide
    Biotin azide is a reagent for click chemistry labeling with biotin, a well-known affinity probe.
  • Chloro-PEG3-Azide
    PEG3 azide chloride contains a reactive halogen atom, and an azide group for Click chemistry reaction. It can also serve as a protected amine group equivalent.
  • Iodo-PEG3-Azide
    Iodo-PEG3-Azide is a bifunctional linker with a highly reactive alkylative halogen functional group, and an azido group for Click chemistry / Staudinger ligation.

Non-fluorescent alkynes

Various non-fluorescent alkynes for copper-catalyzed Click Chemistry. Fluorescent dye alkynes are listed under 'Reactive dyes' category.
  • Alkyne NHS ester (hexynoic acid NHS ester)
    Alkyne NHS ester for the labeling of biomolecules with alkyne group for Copper catalyzed Click chemistry.
  • Alkyne hydrazide
    Bifunctional reagent containing alkyne group and hydrazide function. It reacts with aldehydes and ketones. Alkyne group can then be coupled with various azides via CuAAC reaction.
  • Alkyne maleimide
    Maleimide reagent for the attachment of alkyne functional group to proteins, peptides, and other molecules bearing SH (thiol) groups, including cysteine residues.
  • Biotin alkyne
    Biotin alkyne is a reactive affinity label which can be attached to biomolecules via Click Chemistry.
  • DBCO NHS ester
    Azodibenzocyclooctyne (DBCO, ADIBO) reagent for strain promoted copper free Click chemistry (spAAC). The reagent contains an NHS ester function for the attachment of the cyclooctyne to various molecules.
  • EU (5-ethynyl uridine)
    Uridine alkyne derivative is used for monitoring and investigation of RNA transcription in cells. EU-labeled cellular RNA is detected via CuAAC reaction with fluorescent dye or biotin azides and subsequent fluorescence measurement.
  • EdU (5-ethynyl-2'-deoxyuridine)
    EdU is a nucleoside which is incorporated into replicated DNA by cellular enzymes. After it, DNA contained in the cells can be developed by Click chemistry reaction with fluorescent dye azides to reveal cell proliferation.
  • Hexynoic acid STP ester
    Alkyne activated ester for the modification of amine groups. STP ester group is an excellent alternative to NHS ester functionality.
  • Pentynoic acid STP ester
    An activated ester for the introduction of alkyne into peptides/proteins.
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