Click Chemistry reagents

Lumiprobe provides a comprehensive list of Click Chemistry reagents - azides, alkynes, and auxiliary components.

(are you new to Click Chemistry? Learn more about this technology!)

Fluorescent dye alkynes

Fluorescent dye azides

These azides can be used as reagents for Click Chemistry labeling of alkyne-containing molecules.

Bifunctional adapter molecules

Activated ester reagents can be used to convert amino groups, present in many biomolecules, into azides and alkynes, which are reactive in Click Chemistry

Further reaktive alkynes for the production of Click chemistry compatible molecules:

  • Alkyne hydrazide – for the conversion of aldehydes and ketones to Click-ready alkynes
  • Alkyne maleimide – for converting sulfhydryl groups to Click-ready alkyne groups

Alkyne amidites (phosphoramidites) for solid phase DNA/RNA synthesis

Since the azido group is incompatible with oligo synthesis, only amidites containing alkynes can be used to prepare oligonucleotides for Click Chemistry.

Auxiliary Click Chemistry reagents

Click Chemistry requires Copper(I)-catalysis to take place. To prepare the catalyst, Lumiprobe recommends mixing Cu(II)-TBTA complex with ascorbic acid prior to reaction. Please see our recommended protocols.

  • Copper(II)-TBTA complex – catalyst, stable Cu(II)-form, 10 mM in 55% aq. DMSO
  • Ascorbic acid – recommended reagent to activate stable Cu(II) form of the catalyst prior to reaction
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