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Alkyne solid support for oligo synthesis
| Lot No | Quantity | Price | |
|---|---|---|---|
| 41860 | 1 g | $ 440.00 |
Bulk orders - please inquire.
The solid support can be used for the synthesis of oligonucleotides containing 3'-terminal acetylenic modification.
The compound is a derivative of enantiomerically pure 2-(R)-hydroxybutyrolactone. Solid support is controlled-pore glass, 500 Å pore size.
Coupling conditions. As recommended by synthesizer manufacturer.
Deblock conditions. Standard deblock (ammonia, 6 h at 60°C) recommended. Compatible with AMA and alkali deblock, as well as with UltraMild chemistry.
Oligo purification. PAGE, HPLC, or cartridges.Oligo storage. Not different from standard oligonucleotides.
Resultant oligos are 100%-Click-chemistry compatible.
[1]Dioubankova N.N.; Malakhov, A.D.; Stetsenko, D.A.; Korshun, V.A.; Gait, M.J. (R)-2,4-Dihydroxybutyramide seco-pseudonucleosides: new versatile homochiral synthons for synthesis of modified oligonucleotides. Org Lett., 2002, 4(26), 4607-4610.
[2]Ustinov, A.V.; Dubnyakova, V.V.; Korshun, V.A. A convenient 'click chemistry' approach to perylene diimide-oligonucleotide conjugates. Tetrahedron, 2008, 64(7), 1467-1473.
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